Phone: +1 205 975 2928
Fax: +1 205 934 5499
I am assistant professor in the Department of Pathology at the University
of Alabama at Birmingham (UAB). I was a Marie Curie IOF researcher in the
Bioengineering Department at
Stanford University. I was postdoc for 2 years in the Biocomputing Group
at the University of Bologna (Italy) and 3 years in the Structural
Bioinformatics Unit at CIPF of Valencia (Spain).
I am PhD in physical sciences from the University of Bologna. My scientific background is in Structural Bioinformatics and in the last years my research activity focused on the study of the effect of SNPs resulting in single amino acid polymorphisms. I applied tools for the analysis of protein three-dimensional structure to predict the effect of single point protein mutations on the protein stability developing machine learning methods to evaluate the free energy change due to a given single amino acid polymorphisms (SAPs). More recently, I have been interested to study the relationship between SAPs and the insurgence of human disease. Using information derived from the protein sequence and from the sequence profile, I implemented web server tools to predict disease-related protein variants.
The final goal of my research activity is the understanding of the relationship between genomic variations and disease using large amount of data derived from high-throughput techniques. I am interested to design new disease-specific algorithms and new tools for the personal genomics and personalized medicine. For more details about my scientific activity download my CV.